Pregnancy: Category C. “Poisoning from ethylene glycol is usually accidental, or the result of an attempted suicide.” Because of its physical properties, testing for ethylene glycol requires special equipment and can only be performed at a handful of hospitals and laboratories. Brent J. 2010. Clin Toxicol 48(5):401-6. . Ann Emerg Med. Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings. Ethylene glycol, best known as a component of antifreeze, has been ingested both deliberately and accidentally, resulting in neurotoxicity and renal failure. Drugs 61(7):979-88. The purpose of the present case report was to demonstrate 4-MP efficiency in EG poisoning in a 4-year-old child. Ethylene glycol toxicity is a type of toxic leukoencephalopathy. Fomepizole is a new agent with a specific indication by the U.S. Food and Drug Administration for the treatment of ethylene glycol poisoning.4, 6, … Reproductive Toxicity. Brent J. Amitava Dasgupta, Role of the Laboratory in Detecting Other Poisoning, Including Pesticides, Ethylene Glycol, and Methanol, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring, 10.1002/9781118347867, (139-160), (2012). Carcinogenesis, Mutagenesis, Impairment of Fertility: Long term carcinogenicity studies, genetic toxicity studies and reproductive toxicity studies in animals have not been performed with Polyethylene Glycol 3350, USP Powder for Oral Solution. Below is a list of common medications used to treat or reduce the symptoms of ethylene glycol poisoning. Ethylene glycol polymers with large carbon chains may be reproductive toxins, but ethylene glycol itself exhibits no developmental toxicity or detrimental effects to reproductive health in humans. Current management of ethylene glycol poisoning. 1999. The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a new antidote of ethylene glycol (EG) intoxication. Drug Interactions: No specific drug interactions have been demonstrated. 4-MP Treatment was performed 7 hours after EG ingestion. J.J. Devlin, M. Schwartz, in Encyclopedia of Toxicology (Third Edition), 2014. Method and Results. 53(4):439-450.e10. Fomepizole for the treatment of ethylene glycol poisoning. 2009 Apr. The standard treatment is inhibition of alcohol dehydrogenase with ethanol, given in intoxicating doses, and adjunctive hemodialysis. Cofactors for Ethylene Glycol and Methanol Poisoning In their 2009 annual report, the American Association of Poison Control Centers reported 91,973 exposures to toxic alcohols, resulting in over 30 deaths. Inhalation effects of ethylene glycol with an average concentration in the air up to 140-200 mg / cc. BACKGROUND: Ethylene glycol poisoning causes metabolic acidosis and renal failure and may cause death. Lepik KJ, Levy AR, Sobolev BG, Purssell RA, DeWitt CR, Erhardt GD. Nearly half of these deaths were due to ethylene glycol or methanol. 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